325 S Graham St, Apt No 3
Pittsburgh, PA 15232
908-500-9317 (Cell)

INTERESTS

Computational Biology, Machine Learning, Bioinformatics, Computer Science, and Big Data!

EDUCATION

Carnegie Mellon University, Pittsburgh, PA

M.S. in Computational Biology, May 2013
Joint program - School of Computer Science & Mellon College of Science

Coursework

• Computational Modeling and Simulation
• Machine Learning
• Principles of Software Construction
• Advanced Data Structures and Algorithms
• Imperative Computation
• Cell and Systems Modeling
• Computational Molecular Biology and Genomics
• Computational Chemistry
• Machine Learning for Large Datasets

SRM University, India

B.Tech. In Bioinformatics, May 2011
School of Bioengineering

SKILLS

Programming Languages: Python, MATLAB, C, Java, SML, UNIX, and Shell Scripting.

Software: Minitab, Mathematica, Eclipse and LaTeX.

Bioinformatics Tools: Blast, ClustalW, MEGA 4.0, and Bioinformatics Toolkit-MATLAB.

Computational Chemistry: Gaussian, AMPAC 9.2, ChemSketch, ISIS Draw, and PYMOL.

PROFESSIONAL EXPERIENCE

Systems Programmer II, Magee-Womens Research Institute & Foundation, UPMC-UPCI, Pittsburgh, PA
May 2012 - November 2012

• Ion torrent data re-mapping to identify IN/DELS in homopolymer regions.
• Implementing workflow for analysis of homopolymer regions in the sequence to validate variant calls.
• Integrating NanoString and Affymetrix SNP 6.0 data to validate copy number variations detection in NanoString.
• Characterization estrogen regulated genes with ER-alpha and SRC1.

RESEARCH EXPERIENCE

Research assistant, Carnegie Mellon University, Department of Computational Biology, PA
January 2012 - June 2012

• Mining and analyzing next generation sequencing data. Study steady state abundance of protein across species.
• Using bedtools, samtools, bowtie, and other next gen sequence tools for analysis.

Project Leader, SRM University, Chennai, India
January 2011 - May 2011

• Organizing research and leading the group for the project "Evolutionary Study of Cholinesterase: Comparative and Phylogenetic approach".
• Performing in-silico analysis of Enzyme family Cholinesterases to identify a pattern of evolution.

Research Assistant, Andhra University, Computer Science & Systems Engineering Department, India
May 2010 - July 2010

• Performing in-silico analysis on the mutations of enzyme Butyrylcholinesterase.
• Using phylogenetic analysis to determine the difference between the variants of Human BChE.

Research assistant, Andhra University, International Center for Bioinformatics, India
June 2009 - July 2009

• Examining presence and relation of BChE in bacteria, plants, and lower organisms by phylogenetic methods.
• Demonstrating a possible pathogenic role for BChE in the common existence of insulin resistance, Type 2 diabetes and Alzheimer's disease by in-silico methods.

ACADEMIC PROJECTS

• Built a framework for tweet analysis based on geo location of tweets, using Twitter4J library for search of statuses.
• Framework allows new plugin development and runs them on multiple threads.

• Learn parameters of growth of different cell types from DNA microarray gene expression data involved in brain development.
• Implement a Continuous Time Markov Model to simulate development of the brain connectome.
• Implement similarity-scoring functions of multiple connectomes using graph network theory.
• Code implemented using object-oriented programing in MATLAB.

• Implementing a mass treatment model of syphilis. Performing sensitivity analysis of force of infection.
• Implementing a novel alteration of the Moran Process as a Markov Chain Model to analyze and verify the treatment model.

• Implementing a virtual machine written in C for a new language called C0.
• Executing C0 programs when given compiled C0 code in a byte code format as input.

• Built a molecule viewer as part of term project. The viewer reads in PDB files and displays molecules in 3D.
• The program is based in python. Works as a student tutorial for amino acids.

SELECTED PUBLICATION

• G.R.Sridhar, Nitesh Turaga "Butyrylcholinesterase in metabolic syndrome", Medical Hypotheses journal, Volume 75,Issue 6, Pages 648-651,December 2010.
• "Butyrylcholinesterase: from Pharmacogenetics to Pharmacogenomics" Poster, Baylor College of Medicine, Houston, Nature Genetics and Wellcome Trust, Oct 2010.
• "Re-Look at Butyrylcholinesterase in the Post-Genomic era". Poster Presentation, International Conference on Bioengineering, Chennai, July 2010.

HONORS

Graduate Departmental Fellowship, Carnegie Mellon University 2011-2012, 2012-2013.

LEADERSHIP

• Event Organizer, 98th Indian Science Congress, 2011
• Event Organizer, NCCADD, SRM University, 2011
• Event Organizer, NSBAMS, SRM University, 2009

ACTIVITIES

Pilot- Para glider, Men's Soccer, and Table Tennis Team.